An unliganded thyroid hormone receptor causes severe neurological dysfunction

Congenital hypothyroidism and the thyroid hormone (T(3)) resistance syndrome are associated with severe central nervous system (CNS) dysfunction. Because thyroid hormones are thought to act principally by binding to their nuclear receptors (TRs), it is unexplained why TR knock-out animals are report...

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Detalhes bibliográficos
Main Authors: Hashimoto, Koshi, Curty, Flavio H., Borges, Patricia P., Lee, Charlotte E., Abel, E. Dale, Elmquist, Joel K., Cohen, Ronald N., Wondisford, Fredric E.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC31168/
https://ncbi.nlm.nih.gov/pubmed/11274423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.051454698
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