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An unliganded thyroid hormone receptor causes severe neurological dysfunction

Congenital hypothyroidism and the thyroid hormone (T(3)) resistance syndrome are associated with severe central nervous system (CNS) dysfunction. Because thyroid hormones are thought to act principally by binding to their nuclear receptors (TRs), it is unexplained why TR knock-out animals are report...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Hashimoto, Koshi, Curty, Flavio H., Borges, Patricia P., Lee, Charlotte E., Abel, E. Dale, Elmquist, Joel K., Cohen, Ronald N., Wondisford, Fredric E.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2001
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC31168/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11274423/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.051454698
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