Stereospecificity of Ketoreductase Domains 1 and 2 of the Tylactone Modular Polyketide Synthase

Tylactone synthase (TYLS) is a modular polyketide synthase that catalyzes the formation of tylactone (1), the parent aglycone precursor of the macrolide antibiotic tylosin. TYLS modules 1 and 2 are responsible for the generation of anti-diketide and triketide intermediates, respectively, each bound...

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Bibliografiska uppgifter
Huvudupphovsmän: Castonguay, Roselyne, Valenzano, Chiara R., Chen, Alice Y., Keatinge-Clay, Adrian, Khosla, Chaitan, Cane, David E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2008
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2654278/
https://ncbi.nlm.nih.gov/pubmed/18693734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804453p
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