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Stereospecificity of Ketoreductase Domains 1 and 2 of the Tylactone Modular Polyketide Synthase
Tylactone synthase (TYLS) is a modular polyketide synthase that catalyzes the formation of tylactone (1), the parent aglycone precursor of the macrolide antibiotic tylosin. TYLS modules 1 and 2 are responsible for the generation of anti-diketide and triketide intermediates, respectively, each bound...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2654278/ https://ncbi.nlm.nih.gov/pubmed/18693734 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804453p |
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