Direct interaction between the inhibitor 2 and ceramide via sphingolipid-protein binding is involved in the regulation of protein phosphatase 2A activity and signaling

In this study, the inhibitor 2 of protein phosphatase 2A (I2PP2A) was identified in vitro and in situ as a ceramide-binding protein, which exhibits stereoisomer specificity and fatty acid chain length preference. Site- directed mutagenesis coupled with structural details of I2PP2A suggested that VIK...

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Detalhes bibliográficos
Main Authors: Mukhopadhyay, Archana, Saddoughi, Sahar A., Song, Pengfei, Sultan, Iyad, Ponnusamy, Suriyan, Senkal, Can E., Snook, Christopher F., Arnold, Hugh K., Sears, Rosalie C., Hannun, Yusuf A., Ogretmen, Besim
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653988/
https://ncbi.nlm.nih.gov/pubmed/19028839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.08-120550
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