Wilms’ Tumor 1 Gene Mutations Independently Predict Poor Outcome in Adults With Cytogenetically Normal Acute Myeloid Leukemia: A Cancer and Leukemia Group B Study

PURPOSE: To analyze the prognostic impact of Wilms’ tumor 1 (WT1) gene mutations in cytogenetically normal acute myeloid leukemia (CN-AML). PATIENTS AND METHODS: We studied 196 adults younger than 60 years with newly diagnosed primary CN-AML, who were treated similarly on Cancer and Leukemia Group B...

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Autores principales: Paschka, Peter, Marcucci, Guido, Ruppert, Amy S., Whitman, Susan P., Mrózek, Krzysztof, Maharry, Kati, Langer, Christian, Baldus, Claudia D., Zhao, Weiqiang, Powell, Bayard L., Baer, Maria R., Carroll, Andrew J., Caligiuri, Michael A., Kolitz, Jonathan E., Larson, Richard A., Bloomfield, Clara D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Clinical Oncology 2008
Materias:
Hematologic Malignancies
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653131/
https://ncbi.nlm.nih.gov/pubmed/18559874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.15.2058
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