Patients With Acute Myeloid Leukemia and RAS Mutations Benefit Most From Postremission High-Dose Cytarabine: A Cancer and Leukemia Group B Study

PURPOSE: RAS mutations occur in 12% to 27% of patients with acute myeloid leukemia (AML) and enhance sensitivity to cytarabine in vitro. We examined whether RAS mutations impact response to cytarabine in vivo. PATIENTS AND METHODS: One hundred eighty-five patients with AML achieving complete remissi...

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Détails bibliographiques
Auteurs principaux: Neubauer, Andreas, Maharry, Kati, Mrózek, Krzysztof, Thiede, Christian, Marcucci, Guido, Paschka, Peter, Mayer, Robert J., Larson, Richard A., Liu, Edison T., Bloomfield, Clara D.
Format: Artigo
Langue:Inglês
Publié: American Society of Clinical Oncology 2008
Sujets:
Hematologic Malignancies
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653132/
https://ncbi.nlm.nih.gov/pubmed/18559876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2007.14.0418
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