Mutations of the Wilms tumor 1 gene (WT1) in older patients with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study

We previously reported the adverse prognostic impact of Wilms tumor 1 gene (WT1) mutations in younger adult cytogenetically normal acute myeloid leukemia (CN-AML). Here, we investigated 243 older (≥ 60 years) primary CN-AML patients. WT1 mutated (WT1mut) patients (7%) had FLT3-ITD more frequently (P...

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Autori principali: Becker, Heiko, Marcucci, Guido, Maharry, Kati, Radmacher, Michael D., Mrózek, Krzysztof, Margeson, Dean, Whitman, Susan P., Paschka, Peter, Holland, Kelsi B., Schwind, Sebastian, Wu, Yue-Zhong, Powell, Bayard L., Carter, Thomas H., Kolitz, Jonathan E., Wetzler, Meir, Carroll, Andrew J., Baer, Maria R., Moore, Joseph O., Caligiuri, Michael A., Larson, Richard A., Bloomfield, Clara D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2010
Soggetti:
Clinical Trials and Observations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2918333/
https://ncbi.nlm.nih.gov/pubmed/20442368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-01-262543
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