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Internally Cationic Polyamidoamine PAMAM-OH Dendrimers for siRNA Delivery: Effect of the Degree of Quaternization and Cancer Targeting

A novel cancer targeted, internally cationic, and surface neutral Polyamidoamine (PAMAM) dendrimer was designed, synthesized, and evaluated as a nanocarrier for the targeted intracellular delivery of siRNA. The dendrimer contained a synthetic analog of Luteinizing Hormone-Releasing Hormone as cancer...

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Autori principali: Patil, Mahesh L., Zhang, Min, Taratula, Oleh, Garbuzenko, Olga B., He, Huixin, Minko, Tamara
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653103/
https://ncbi.nlm.nih.gov/pubmed/19159248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bm8009973
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