Surface-Engineered Targeted PPI Dendrimer for Efficient Intracellular and Intratumoral siRNA Delivery

Low penetration ability of Small Interfering RNA (siRNA) through the cellular plasma membrane combined with its limited stability in blood, limits the effectiveness of the systemic delivery of siRNA. In order to overcome such difficulties, we constructed a nanocarrier-based delivery system by taking...

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Main Authors: Taratula, Oleh, Garbuzenko, Olga B., Kirkpatrick, Paul, Pandya, Ipsit, Savla, Ronak, Pozharov, Vitaly P., He, Huixin, Minko, Tamara
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2787988/
https://ncbi.nlm.nih.gov/pubmed/19567257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2009.06.019
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