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Acetylation of PAMAM dendrimers for cellular delivery of siRNA

BACKGROUND: The advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery proce...

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Detalhes bibliográficos
Main Authors: Waite, Carolyn L, Sparks, Sarah M, Uhrich, Kathryn E, Roth, Charles M
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679008/
https://ncbi.nlm.nih.gov/pubmed/19389227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6750-9-38
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