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Efficient in vitro siRNA delivery and Intramuscular Gene Silencing using PEG-modified PAMAM Dendrimers

Although siRNA techniques have been broadly applied as a tool for gene knockdown, substantial challenges remain in achieving efficient delivery and in vivo efficacy. In particular, the low efficiency of target gene silencing in vivo is a critical limiting step to the clinical application of siRNA th...

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Bibliografiska uppgifter
Huvudupphovsmän: Tang, Yin, Li, Yang-Bing, Wang, Bo, Lin, Ri-Yuan, van Dongen, Mallory, Zurcher, Danielle M., Gu, Xiao-Yan, Banaszak Holl, Mark M., Liu, George, Qi, Rong
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3375318/
https://ncbi.nlm.nih.gov/pubmed/22548294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp3001364
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