Induction of topoisomerase I cleavage complexes by 1-β-d-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells

1-β-d-Arabinofuranosylcytosine (Ara-C) is a nucleoside analog commonly used in the treatment of leukemias. Ara-C inhibits DNA polymerases and can be incorporated into DNA. Its mechanism of cytotoxicity is not fully understood. Using oligonucleotides and purified human topoisomerase I (top1), we foun...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Pourquier, Philippe, Takebayashi, Yuji, Urasaki, Yoshimasa, Gioffre, Christopher, Kohlhagen, Glenda, Pommier, Yves
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 2000
Témata:	Biological Sciences
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26531/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10677551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.4.1885
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