Loading...

Induction of topoisomerase I cleavage complexes by 1-β-d-arabinofuranosylcytosine (ara-C) in vitro and in ara-C-treated cells

1-β-d-Arabinofuranosylcytosine (Ara-C) is a nucleoside analog commonly used in the treatment of leukemias. Ara-C inhibits DNA polymerases and can be incorporated into DNA. Its mechanism of cytotoxicity is not fully understood. Using oligonucleotides and purified human topoisomerase I (top1), we foun...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Pourquier, Philippe, Takebayashi, Yuji, Urasaki, Yoshimasa, Gioffre, Christopher, Kohlhagen, Glenda, Pommier, Yves
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC26531/
https://ncbi.nlm.nih.gov/pubmed/10677551
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!