Synthesis and evaluation of Apogossypol Atropisomers as Potential Bcl-x(L) Antagonists

Anti-apoptotic Bcl-2 family proteins such as Bcl-2 and Bcl-X(L) have been recently validated as targets for the discovery of novel anti-cancer agents. We previously reported that racemic (+/−) Apogossypol, a semi-synthetic compound derived from the natural product Gossypol, binds and inhibits Bcl-2...

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Main Authors: Wei, Jun, Rega, Michele F., Kitada, Shinichi, Yuan, Hongbin, Zhai, Dayong, Risbood, Prabhakar, Seltzman, Herbert H., Twine, Charles E., Reed, John C., Pellecchia, Maurizio
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2653056/
https://ncbi.nlm.nih.gov/pubmed/18782651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.07.031
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