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Synthesis and evaluation of Apogossypol Atropisomers as Potential Bcl-x(L) Antagonists
Anti-apoptotic Bcl-2 family proteins such as Bcl-2 and Bcl-X(L) have been recently validated as targets for the discovery of novel anti-cancer agents. We previously reported that racemic (+/−) Apogossypol, a semi-synthetic compound derived from the natural product Gossypol, binds and inhibits Bcl-2...
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| Hlavní autoři: | , , , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2653056/ https://ncbi.nlm.nih.gov/pubmed/18782651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2008.07.031 |
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