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Population Pharmacokinetics of Cyclophosphamide and Metabolites in Children with Neuroblastoma: a Report from the Children’s Oncology Group

Cyclophosphamide-based regimens are front-line treatment for numerous pediatric malignancies, however current dosing methods result in considerable interpatient variability in tumor response and toxicity. In this pediatric population, our objectives were to 1. quantify and explain the pharmacokineti...

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Hlavní autoři: McCune, Jeannine S., Salinger, David H., Vicini, Paolo, Oglesby, Celeste, Blough, David K., Park, Julie R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652687/
https://ncbi.nlm.nih.gov/pubmed/18927240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0091270008325928
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