POPULATION PHARMACOKINETIC/DYNAMIC MODEL OF LYMPHOSUPPRESSION AFTER FLUDARABINE ADMINISTRATION

PURPOSE: Quantitative relationships between 9-β-D-arabinofuranosyl-2-fluoroadenine (F-ara-A) concentrations and lymphosuppression have not been reported, but would be useful for regimen design. A population pharmacokinetic/pharmacodynamic model was constructed in this study using data from 41 hemato...

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Detalhes bibliográficos
Publicado no:Cancer Chemother Pharmacol
Main Authors: McCune, Jeannine S., Vicini, Paolo, Salinger, David H., O’Donnell, Paul V., Sandmaier, Brenda M., Anasetti, Claudio, Mager, Donald E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4282607/
https://ncbi.nlm.nih.gov/pubmed/25374408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-014-2618-2
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