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Abnormal Brain Iron Homeostasis in Human and Animal Prion Disorders
Neurotoxicity in all prion disorders is believed to result from the accumulation of PrP-scrapie (PrP(Sc)), a β-sheet rich isoform of a normal cell-surface glycoprotein, the prion protein (PrP(C)). Limited reports suggest imbalance of brain iron homeostasis as a significant associated cause of neurot...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2009
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652663/ https://ncbi.nlm.nih.gov/pubmed/19283067 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000336 |
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