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Modulation of Proteinase K-resistant Prion Protein in Cells and Infectious Brain Homogenate by Redox Iron: Implications for Prion Replication and Disease Pathogenesis

The principal infectious and pathogenic agent in all prion disorders is a β-sheet–rich isoform of the cellular prion protein (PrP(C)) termed PrP-scrapie (PrP(Sc)). Once initiated, PrP(Sc) is self-replicating and toxic to neuronal cells, but the underlying mechanisms remain unclear. In this report, w...

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Main Authors: Basu, Subhabrata, Mohan, Maradumane L., Luo, Xiu, Kundu, Bishwajit, Kong, Qingzhong, Singh, Neena
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Cell Biology 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951779/
https://ncbi.nlm.nih.gov/pubmed/17567949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-04-0317
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