Prion protein facilitates retinal iron uptake and is cleaved at the β-site: Implications for retinal iron homeostasis in prion disorders

Prion disease-associated retinal degeneration is attributed to PrP-scrapie (PrP(Sc)), a misfolded isoform of prion protein (PrP(C)) that accumulates in the neuroretina. However, a lack of temporal and spatial correlation between PrP(Sc) and cytotoxicity suggests the contribution of host factors. We...

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Publicado no:Sci Rep
Main Authors: Asthana, Abhishek, Baksi, Shounak, Ashok, Ajay, Karmakar, Shilpita, Mammadova, Najiba, Kokemuller, Robyn, Greenlee, Mary Heather, Kong, Qingzhong, Singh, Neena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5575325/
https://ncbi.nlm.nih.gov/pubmed/28851903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08821-1
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