Abnormal Brain Iron Homeostasis in Human and Animal Prion Disorders

Neurotoxicity in all prion disorders is believed to result from the accumulation of PrP-scrapie (PrP(Sc)), a β-sheet rich isoform of a normal cell-surface glycoprotein, the prion protein (PrP(C)). Limited reports suggest imbalance of brain iron homeostasis as a significant associated cause of neurot...

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Bibliografiska uppgifter
Huvudupphovsmän: Singh, Ajay, Isaac, Alfred Orina, Luo, Xiu, Mohan, Maradumane L., Cohen, Mark L., Chen, Fusong, Kong, Qingzhong, Bartz, Jason, Singh, Neena
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2009
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652663/
https://ncbi.nlm.nih.gov/pubmed/19283067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000336
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