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Cyst Formation in Kidney via B-Raf Signaling in the PKD2 Transgenic Mice
The pathogenic mechanisms of human autosomal dominant polycystic kidney disease (ADPKD) have been well known to include the mutational inactivation of PKD2. Although haploinsufficiency and loss of heterozygosity at the Pkd2 locus can cause cyst formation in mice, polycystin-2 is frequently expressed...
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| 主要な著者: | , , , , , , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Biochemistry and Molecular Biology
2009
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2652279/ https://ncbi.nlm.nih.gov/pubmed/19098310 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805890200 |
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