Cyst Formation in Kidney via B-Raf Signaling in the PKD2 Transgenic Mice

The pathogenic mechanisms of human autosomal dominant polycystic kidney disease (ADPKD) have been well known to include the mutational inactivation of PKD2. Although haploinsufficiency and loss of heterozygosity at the Pkd2 locus can cause cyst formation in mice, polycystin-2 is frequently expressed...

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Autori principali: Park, Eun Young, Sung, Young Hoon, Yang, Moon Hee, Noh, Ji Yeun, Park, So Young, Lee, Tae Young, Yook, Yeon Joo, Yoo, Kyung Hyun, Roh, Kyung Jin, Kim, Ingyu, Hwang, Young-Hwan, Oh, Goo Taeg, Seong, Je Kyung, Ahn, Curie, Lee, Han-Woong, Park, Jong Hoon
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652279/
https://ncbi.nlm.nih.gov/pubmed/19098310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805890200
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