Autophagy induction promotes renal cyst growth in polycystic kidney disease

BACKGROUND: Polycystic kidney disease (PKD) involves renal cysts arising from proliferating tubular cells. Autophagy has been recently suggested as a potential therapeutic target in PKD, and mammalian target of rapamycin (mTOR) is a key negative regulator of autophagy. However, the effect of autopha...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Lee, Eun Ji, Ko, Je Yeong, Oh, Sumin, Jun, Jaehee, Mun, Hyowon, Lim, Chae Ji, Seo, Seungwoon, Ko, Hyuk Wan, Kim, Hyunho, Oh, Yun Kyu, Ahn, Curie, Kang, Minyong, Kim, Min Jung, Yoo, Kyung Hyun, Oh, Goo Taeg, Park, Jong Hoon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7501056/
https://ncbi.nlm.nih.gov/pubmed/32949996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.102986
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