Lapatinib (Tykerb, GW572016) Reverses Multidrug Resistance in Cancer Cells by Inhibiting the Activity of ATP-Binding Cassette Subfamily B Member 1 and G Member 2

Lapatinib is active at the ATP-binding site of tyrosine kinases that are associated with the human epidermal growth factor receptor (EGFR, Her-1, or ErbB1) and Her-2. It is conceivable that lapatinib may inhibit the function of ATP-binding cassette (ABC) transporters by binding to their ATP-binding...

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Detalhes bibliográficos
Main Authors: Dai, Chun-ling, Tiwari, Amit K., Wu, Chung-Pu, Su, Xiao-dong, Wang, Si-Rong, Liu, Dong-geng, Ashby, Charles R., Huang, Yan, Robey, Robert W., Liang, Yong-ju, Chen, Li-ming, Shi, Cheng-Jun, Ambudkar, Suresh V., Chen, Zhe-Sheng, Fu, Li-wu
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2652245/
https://ncbi.nlm.nih.gov/pubmed/18829547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0499
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