Increased mechanosensitivity and nuclear stiffness in Hutchinson-Gilford progeria cells: Effects of farnesyltransferase inhibitors

Hutchinson-Gilford progeria syndrome (HGPS), reportedly a model for normal aging, is a genetic disorder in children marked by dramatic signs suggestive for premature aging. It is usually caused by de novo mutations in the nuclear envelope protein lamin A. Lamins are essential to maintain nuclear int...

Full description

Saved in:
Bibliographic Details
Main Authors: Verstraeten, Valerie L.R.M., Ji, Julie Y., Cummings, Kiersten S., Lee, Richard T., Lammerding, Jan
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2651412/
https://ncbi.nlm.nih.gov/pubmed/18331619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2008.00382.x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items