Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue

The diarylquinoline TMC207 kills Mycobacterium tuberculosis by specifically inhibiting ATP synthase. We show here that human mitochondrial ATP synthase (50% inhibitory concentration [IC(50)] of >200 μM) displayed more than 20,000-fold lower sensitivity for TMC207 compared to that of mycobacterial...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Haagsma, Anna C., Abdillahi-Ibrahim, Rooda, Wagner, Marijke J., Krab, Klaas, Vergauwen, Karen, Guillemont, Jerome, Andries, Koen, Lill, Holger, Koul, Anil, Bald, Dirk
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology (ASM) 2009
Aiheet:
Mechanisms of Action: Physiological Effects
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650532/
https://ncbi.nlm.nih.gov/pubmed/19075053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01393-08
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia