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Prevention of Drug Carryover Effects in Studies Assessing Antimycobacterial Efficacy of TMC207
The levels of TMC207 (R207910) that can be reached in mouse organs and the sputa of treated patients easily exceed the MIC of the compound and can therefore interfere with in vitro bacterial titrations. We studied the usefulness of protein-enriched media for the prevention of such drug carryover eff...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2446915/ https://ncbi.nlm.nih.gov/pubmed/18480227 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JCM.00177-08 |
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