Targeting Energy Metabolism in Mycobacterium tuberculosis, a New Paradigm in Antimycobacterial Drug Discovery

Por Bald, Dirk, Villellas, Cristina, Lu, Ping, Koul, Anil
Publicado no mBio (2017)

Probing the Interaction of the Diarylquinoline TMC207 with Its Target Mycobacterial ATP Synthase

Por Haagsma, Anna C., Podasca, Ioana, Koul, Anil, Andries, Koen, Guillemont, Jerome, Lill, Holger, Bald, Dirk
Publicado em 2011

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd

Por Lu, Ping, Asseri, Amer H., Kremer, Martijn, Maaskant, Janneke, Ummels, Roy, Lill, Holger, Bald, Dirk
Publicado no Sci Rep (2018)

Two-stimuli manipulation of a biological motor

Por Ristic, Zorica, Vitali, Marco, Duci, Alessandro, Goetze, Christian, Kemnitz, Klaus, Zuschratter, Werner, Lill, Holger, Bald, Dirk
Publicado em 2009

Pyrazinoic Acid Decreases the Proton Motive Force, Respiratory ATP Synthesis Activity, and Cellular ATP Levels

Por Lu, Ping, Haagsma, Anna C., Pham, Hoang, Maaskant, Janneke J., Mol, Selena, Lill, Holger, Bald, Dirk
Publicado em 2011

Cytochrome bd Displays Significant Quinol Peroxidase Activity

Por Al-Attar, Sinan, Yu, Yuanjie, Pinkse, Martijn, Hoeser, Jo, Friedrich, Thorsten, Bald, Dirk, de Vries, Simon
Publicado no Sci Rep (2016)

The cytochrome bd-type quinol oxidase is important for survival of Mycobacterium smegmatis under peroxide and antibiotic-induced stress

Por Lu, Ping, Heineke, Marieke H., Koul, Anil, Andries, Koen, Cook, Gregory M., Lill, Holger, van Spanning, Rob, Bald, Dirk
Publicado no Sci Rep (2015)

Direct quantitative detection of Doc2b-induced hemifusion in optically trapped membranes

Por Brouwer, Ineke, Giniatullina, Asiya, Laurens, Niels, van Weering, Jan R. T., Bald, Dirk, Wuite, Gijs J. L., Groffen, Alexander J.
Publicado no Nat Commun (2015)

A fluorescence-based reporter for monitoring expression of mycobacterial cytochrome bd in response to antibacterials and during infection

Por Boot, Maikel, Jim, Kin Ki, Liu, Ting, Commandeur, Susanna, Lu, Ping, Verboom, Theo, Lill, Holger, Bitter, Wilbert, Bald, Dirk
Publicado no Sci Rep (2017)

Ionophoric effects of the antitubercular drug bedaquiline

Por Hards, Kiel, McMillan, Duncan G. G., Schurig-Briccio, Lici A., Gennis, Robert B., Lill, Holger, Bald, Dirk, Cook, Gregory M.
Publicado no Proc Natl Acad Sci U S A (2018)

Selectivity of TMC207 towards Mycobacterial ATP Synthase Compared with That towards the Eukaryotic Homologue

Por Haagsma, Anna C., Abdillahi-Ibrahim, Rooda, Wagner, Marijke J., Krab, Klaas, Vergauwen, Karen, Guillemont, Jerome, Andries, Koen, Lill, Holger, Koul, Anil, Bald, Dirk
Publicado em 2009

Delayed bactericidal response of Mycobacterium tuberculosis to bedaquiline involves remodelling of bacterial metabolism

Por Koul, Anil, Vranckx, Luc, Dhar, Neeraj, Göhlmann, Hinrich W.H., Özdemir, Emre, Neefs, Jean-Marc, Schulz, Melanie, Lu, Ping, Mørtz, Ejvind, McKinney, John D., Andries, Koen, Bald, Dirk
Publicado em 2014

Novel Antibiotics Targeting Respiratory ATP Synthesis in Gram-Positive Pathogenic Bacteria

Por Balemans, Wendy, Vranckx, Luc, Lounis, Nacer, Pop, Ovidiu, Guillemont, Jérôme, Vergauwen, Karen, Mol, Selena, Gilissen, Ron, Motte, Magali, Lançois, David, De Bolle, Miguel, Bonroy, Kristien, Lill, Holger, Andries, Koen, Bald, Dirk, Koul, Anil
Publicado em 2012