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Ionophoric effects of the antitubercular drug bedaquiline

Bedaquiline (BDQ), an inhibitor of the mycobacterial F(1)F(o)-ATP synthase, has revolutionized the antitubercular drug discovery program by defining energy metabolism as a potent new target space. Several studies have recently suggested that BDQ ultimately causes mycobacterial cell death through a p...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Hards, Kiel, McMillan, Duncan G. G., Schurig-Briccio, Lici A., Gennis, Robert B., Lill, Holger, Bald, Dirk, Cook, Gregory M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6048524/
https://ncbi.nlm.nih.gov/pubmed/29941569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1803723115
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