CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity

Mutation in leucine-rich repeat kinase-2 (LRRK2) is the most common cause of late-onset Parkinson's disease (PD). Although most cases of PD are sporadic, some are inherited, including those caused by LRRK2 mutations. Because these mutations may be associated with a toxic gain of function, contr...

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Autors principals: Ko, Han Seok, Bailey, Rachel, Smith, Wanli W., Liu, Zhaohui, Shin, Joo-Ho, Lee, Yun-Il, Zhang, Yong-Jie, Jiang, Haibing, Ross, Christopher A., Moore, Darren J., Patterson, Cam, Petrucelli, Leonard, Dawson, Ted M., Dawson, Valina L.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650345/
https://ncbi.nlm.nih.gov/pubmed/19196961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0810123106
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