Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

Mutations in the leucine-rich repeat kinase 2 gene (LRRK2) cause late-onset Parkinson's disease (PD) with a clinical appearance indistinguishable from idiopathic PD. Initial studies suggest that LRRK2 mutations are the most common yet identified determinant of PD susceptibility, transmitted in...

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Detalhes bibliográficos
Main Authors: West, Andrew B., Moore, Darren J., Biskup, Saskia, Bugayenko, Artem, Smith, Wanli W., Ross, Christopher A., Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1283829/
https://ncbi.nlm.nih.gov/pubmed/16269541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0507360102
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