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Oncogenic EGFR signaling cooperates with loss of tumor suppressor gene functions in gliomagenesis

Glioblastoma multiforme (GBM) is a highly lethal brain tumor for which little treatment is available. The epidermal growth factor receptor (EGFR) signaling pathway is thought to play a crucial role in GBM pathogenesis, initiating the early stages of tumor development, sustaining tumor growth, promot...

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Autors principals: Zhu, Haihao, Acquaviva, Jaime, Ramachandran, Pranatartiharan, Boskovitz, Abraham, Woolfenden, Steve, Pfannl, Rolf, Bronson, Roderick T., Chen, John W., Weissleder, Ralph, Housman, David E., Charest, Al
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2650331/
https://ncbi.nlm.nih.gov/pubmed/19196966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0813314106
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