Mig-6 controls EGFR trafficking and suppresses gliomagenesis

Glioblastoma multiforme (GBM) is the most common and lethal primary brain cancer that is driven by aberrant signaling of growth factor receptors, particularly the epidermal growth factor receptor (EGFR). EGFR signaling is tightly regulated by receptor endocytosis and lysosome-mediated degradation, a...

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Autori principali: Ying, Haoqiang, Zheng, Hongwu, Scott, Kenneth, Wiedemeyer, Ruprecht, Yan, Haiyan, Lim, Carol, Huang, Joseph, Dhakal, Sabin, Ivanova, Elena, Xiao, Yonghong, Zhang, Hailei, Hu, Jian, Stommel, Jayne M., Lee, Michelle A., Chen, An-Jou, Paik, Ji-Hye, Segatto, Oreste, Brennan, Cameron, Elferink, Lisa A., Wang, Y. Alan, Chin, Lynda, DePinho, Ronald A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2010
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872443/
https://ncbi.nlm.nih.gov/pubmed/20351267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0914930107
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