Acquired MET Expression Confers Resistance to EGFR Inhibition In a Mouse Model of Glioblastoma Multiforme

Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type EGFR and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient features of this deadly cancer. Surprisingly, targeted inhibition of EGFR has been clinically disappointing, d...

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Détails bibliographiques
Auteurs principaux: Jun, Hyun Jung, Acquaviva, Jaime, Chi, Dorcas, Lessard, Julie, Zhu, Haihao, Woolfenden, Steve, Bronson, Roderick T., Pfannl, Rolf, White, Forest, Housman, David E., Iyer, Lakshmanan, Whittaker, Charles A., Boskovitz, Abraham, Raval, Ami, Charest, Alain
Format: Artigo
Langue:Inglês
Publié: 2011
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774279/
https://ncbi.nlm.nih.gov/pubmed/22020333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.474
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