Acquired MET Expression Confers Resistance to EGFR Inhibition In a Mouse Model of Glioblastoma Multiforme

Glioblastoma Multiforme (GBM) is an aggressive brain tumor for which there is no cure. Overexpression of wild-type EGFR and loss of the tumor suppressor genes Ink4a/Arf and PTEN are salient features of this deadly cancer. Surprisingly, targeted inhibition of EGFR has been clinically disappointing, d...

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Autori principali: Jun, Hyun Jung, Acquaviva, Jaime, Chi, Dorcas, Lessard, Julie, Zhu, Haihao, Woolfenden, Steve, Bronson, Roderick T., Pfannl, Rolf, White, Forest, Housman, David E., Iyer, Lakshmanan, Whittaker, Charles A., Boskovitz, Abraham, Raval, Ami, Charest, Alain
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3774279/
https://ncbi.nlm.nih.gov/pubmed/22020333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.474
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