Chronic Activation of Wild Type Epidermal Growth Factor Receptor and Loss of Cdkn2a Cause Mouse Glioblastoma Formation

Glioblastoma multiforme (GBM) is characterized by overexpression of EGFR and loss of the tumor suppressors Ink4a/Arf. Efforts at modeling GBM using wild-type EGFR in mice have proven unsuccessful. Here, we present a unique mouse model of wild-type EGFR-driven gliomagenesis. We used a combination of...

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Autors principals: Acquaviva, Jaime, Jun, Hyun Jung, Lessard, Julie, Ruiz, Rolando, Zhu, Haihao, Donovan, Melissa, Woolfenden, Steve, Boskovitz, Abraham, Raval, Ami, Bronson, Roderick T., Pfannl, Rolf, Whittaker, Charles A., Housman, David E., Charest, Al
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228869/
https://ncbi.nlm.nih.gov/pubmed/21987724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-1514
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