Microglial inhibition of neuroprotection by antagonists of the EP1 prostaglandin E2 receptor

BACKGROUND: The EP1 receptor for the prostanoid PGE2 is a G-protein coupled receptor that has been shown to contribute to excitotoxic neuronal death. In this study we examined the influence of non-neuronal cells on neuroprotective properties of EP1 receptor antagonists (Ono 8711 and SC 51089). METHO...

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Autori principali: Carlson, Noel G, Rojas, Monica A, Black, John-David, Redd, Jonathan W, Hille, John, Hill, Kenneth E, Rose, John W
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2009
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2649915/
https://ncbi.nlm.nih.gov/pubmed/19222857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-6-5
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