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Differential role of beta-arrestin ubiquitination in agonist-promoted down-regulation of M(1 )vs M(2 )muscarinic acetylcholine receptors
BACKGROUND: Sustained agonist-promoted ubiquitination of β-arrestin has been correlated with increased stability of the GPCR – β-arrestin complex. Moreover, abrogation of β-arrestin ubiquitination has been reported to inhibit receptor internalization with minimal effects on receptor degradation. RES...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2648954/ https://ncbi.nlm.nih.gov/pubmed/19055777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-2187-3-20 |
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