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Fragment-based identification of druggable ‘hot spots’ of proteins using Fourier domain correlation techniques
Motivation: The binding sites of proteins generally contain smaller regions that provide major contributions to the binding free energy and hence are the prime targets in drug design. Screening libraries of fragment-sized compounds by NMR or X-ray crystallography demonstrates that such ‘hot spot’ re...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2647826/ https://ncbi.nlm.nih.gov/pubmed/19176554 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btp036 |
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