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The catalytic subunit of DNA-dependent protein kinase selectively regulates p53-dependent apoptosis but not cell-cycle arrest

DNA damage induced by ionizing radiation (IR) activates p53, leading to the regulation of downstream pathways that control cell-cycle progression and apoptosis. However, the mechanisms for the IR-induced p53 activation and the differential activation of pathways downstream of p53 are unclear. Here w...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wang, Sa, Guo, Min, Ouyang, Honghai, Li, Xiaoling, Cordon-Cardo, Carlos, Kurimasa, Akihiro, Chen, David J., Fuks, Zvi, Ling, C. Clifton, Li, Gloria C.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2000
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26478/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10677503/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.97.4.1584
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