Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is an enormous, 470-kDa protein serine/threonine kinase that has homology with members of the phosphatidylinositol (PI) 3-kinase superfamily. This protein contributes to the repair of DNA double-strand breaks (DSBs) by assembling broke...

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Detalhes bibliográficos
Main Authors: Kurimasa, Akihiro, Kumano, Satoshi, Boubnov, Nikolai V., Story, Michael D., Tung, Chang-Shung, Peterson, Scott R., Chen, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
DNA Dynamics and Chromosome Structure
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC84245/
https://ncbi.nlm.nih.gov/pubmed/10207111
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