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Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining

The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is an enormous, 470-kDa protein serine/threonine kinase that has homology with members of the phosphatidylinositol (PI) 3-kinase superfamily. This protein contributes to the repair of DNA double-strand breaks (DSBs) by assembling broke...

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Autors principals: Kurimasa, Akihiro, Kumano, Satoshi, Boubnov, Nikolai V., Story, Michael D., Tung, Chang-Shung, Peterson, Scott R., Chen, David J.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC84245/
https://ncbi.nlm.nih.gov/pubmed/10207111
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