Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

The DNA-dependent protein kinase (DNA-PK) consists of three polypeptide components: Ku-70, Ku-80, and an approximately 350-kDa catalytic subunit (p350). The gene encoding the Ku-80 subunit is identical to the x-ray-sensitive group 5 complementing gene XRCC5. Expression of the Ku-80 cDNA rescues both...

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Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Peterson, S R, Kurimasa, A, Oshimura, M, Dynan, W S, Bradbury, E M, Chen, D J
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1995
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC42127/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7724535/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.8.3171
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