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GTP cyclohydrolase I expression and enzymatic activity are present in caveolae of endothelial cells

Tetrahydrobiopterin is an essential cofactor required for the synthesis of nitric oxide. GTP cyclohydrolase I (GTPCH I) is the rate limiting enzyme for tetrahydrobiopterin production in endothelial cells, yet little is known about the subcellular localization of this enzyme. In this study, we demons...

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Autors principals: Peterson, Timothy E., d’Uscio, Livius V., Cao, Sheng, Wang, Xiao-Li, Katusic, Zvonimir S.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646898/
https://ncbi.nlm.nih.gov/pubmed/19104007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.108.115709
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