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Identification of Adducts Formed in the Reactions of 5′-Acetoxy-N′-nitrosonornicotine with Deoxyadenosine, Thymidine, and DNA

N′-Nitrosonornicotine (NNN) is the most prevalent of the carcinogenic tobacco-specific nitrosamines found in all tobacco products. Previous studies have demonstrated that cytochrome-P450 mediated 5′-hydroxylation of NNN is a major metabolic pathway leading to mutagenic products, but to date DNA addu...

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Bibliografiske detaljer
Main Authors: Upadhyaya, Pramod, Hecht, Stephen S.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646895/
https://ncbi.nlm.nih.gov/pubmed/18821782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx8002559
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