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Evaluating a surrogate endpoint at three levels, with application to vaccine development
Identification of an immune response to vaccination that reliably predicts protection from clinically significant infection, i.e. an immunological surrogate endpoint, is a primary goal of vaccine research. Using this problem of evaluating an immunological surrogate as an illustration, we describe a...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2646675/ https://ncbi.nlm.nih.gov/pubmed/17979212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3122 |
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