Molecular Mechanism of Action of Pharmacoperone Rescue of Misrouted GPCR Mutants: The GnRH Receptor

The human GnRH receptor (hGnRHR), a G protein-coupled receptor, is a useful model for studying pharmacological chaperones (pharmacoperones), drugs that rescue misfolded and misrouted protein mutants and restore them to function. This technique forms the basis of a therapeutic approach of rescuing mu...

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Detaylı Bibliyografya
Asıl Yazarlar: Janovick, Jo Ann, Patny, Akshay, Mosley, Ralph, Goulet, Mark T., Altman, Michael D., Rush, Thomas S., Cornea, Anda, Conn, P. Michael
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Endocrine Society 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2646616/
https://ncbi.nlm.nih.gov/pubmed/19095769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2008-0384
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