FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells

Novel immunomodulatory molecule FTY720 is a synthetic analog of myriocin, but unlike myriocin FTY720 does not inhibit serine palmitoyltransferase. Although many of the effects of FTY720 are ascribed to its phosphorylation and subsequent sphingosine 1-phosphate (S1P)-like action through S1P(1,3–5) re...

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Hauptverfasser: Berdyshev, Evgeny V., Gorshkova, Irina, Skobeleva, Anastasia, Bittman, Robert, Lu, Xuequan, Dudek, Steven M., Mirzapoiazova, Tamara, Garcia, Joe G. N., Natarajan, Viswanathan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645812/
https://ncbi.nlm.nih.gov/pubmed/19119142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M805186200
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