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Dual inhibition of PI3Kα and mTOR as an alternative treatment for Kaposi's sarcoma

Rapamycin (or sirolimus), the prototypical inhibitor of the mammalian target of rapamycin (mTOR) and an immunosuppressant used for the prevention of renal transplant rejection, has recently emerged as an effective treatment for Kaposi's sarcoma (KS), an enigmatic vascular tumor and a model for...

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Hlavní autoři: Chaisuparat, Risa, Hu, Jiadi, Jham, Bruno C., Knight, Zachary A., Shokat, Kevan M., Montaner, Silvia
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645787/
https://ncbi.nlm.nih.gov/pubmed/18922908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-0878
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